A6 - BARBARIANS AT THE GATE: VIRUSES AND THE AIRWAY EPITHELIUM IN ASTHMA
09:15 AM - 11:15 AM
Ballroom A (South Building, Level 3), Walter E. Washington Convention Center
Viral respiratory infections are the most common causes of wheezing in infants and young children and are associated with an increased risk of developing childhood asthma. In addition, viral respiratory infections are common triggers of asthma exacerbations in adult and pediatric patients with pre-existing asthma. The mechanisms by which viral respiratory infections increase future risk of asthma and cause asthma exacerbations are uncertain. Investigators in the NIAID-funded Asthma and Allergic Disease Cooperative Research Center (AADCRC) shed light on these mechanisms through basic, translational and clinical investigation. These studies have yielded new insights into the central role of viral infection in the pathogenesis of asthma and the role that the airway epithelium plays in mediating host-virus interactions. This symposium will present these new discoveries and place them in the context of human disease.